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  • Writer's pictureSinead Mackintosh

Drug Metabolism

Drug metabolism is a fascinating topic that has captivated scientists for years. It refers to the way in which our bodies process drugs, and it's a process that is heavily influenced by our genetics. You see, drug metabolism is largely controlled by a group of enzymes called cytochrome P450 enzymes. These enzymes are responsible for breaking down drugs in the liver, which allows them to be eliminated from the body.

However, the way in which these enzymes work is heavily influenced by our genetics. Some people have genetic variations that cause them to produce more or less of these enzymes, which can affect how quickly drugs are eliminated from their bodies. This can have a huge impact on how effective drugs are at treating certain conditions, as well as how safe they are to use.

Let use blood pressure medicine for example.

If someone has a genetic variation that causes them to produce less of the enzymes that break down this drug, it may stay in their system for longer than intended. This could lead to dangerously low blood pressure levels, which could be life-threatening.

On the other hand, if someone has a genetic variation that causes them to produce more of these enzymes, the drug may be eliminated from their system too quickly. This could result in the drug being less effective at treating their condition.

Understanding the genetics behind drug metabolism is crucial for developing safe and effective drugs.

By considering the genetic variations that exist within the population, scientists can design drugs that are tailored to work best for everyone. This is known as personalised medicine, and it has the potential to revolutionize the way we treat diseases.

In conclusion, the genetics behind drug metabolism is a complex and fascinating topic that has far-reaching implications for our health and well-being. By continuing to study this area, we can develop safer and more effective drugs that are tailored to everyone’s unique genetic makeup.


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